[HTML][HTML] Cortico-efferent tract involvement in primary lateral sclerosis and amyotrophic lateral sclerosis: a two-centre tract of interest-based DTI analysis
HP Müller, F Agosta, M Gorges, R Kassubek… - NeuroImage: Clinical, 2018 - Elsevier
Background After the demonstration of a corticoefferent propagation pattern in amyotrophic
lateral sclerosis (ALS) by neuropathological studies, this concept has been used for in vivo
staging of individual patients by diffusion tensor imaging (DTI) techniques, both
inclassicalALS and in restricted phenotypes such as primary lateral sclerosis (PLS).
Objective The study was designed to investigate that microstructural changes according to
the neuropathologically defined ALS alteration pattern in PLS patients could be confirmed to …
lateral sclerosis (ALS) by neuropathological studies, this concept has been used for in vivo
staging of individual patients by diffusion tensor imaging (DTI) techniques, both
inclassicalALS and in restricted phenotypes such as primary lateral sclerosis (PLS).
Objective The study was designed to investigate that microstructural changes according to
the neuropathologically defined ALS alteration pattern in PLS patients could be confirmed to …
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